ABSTRACT
A healthy full-term female neonate, aged 3 days and born by vaginal delivery (with a 1-minute Apgar score of 10 and a 5-minute Apgar score of 10), had unexpected cardiac and respiratory arrests in the early morning on day 3 after birth and recovered to spontaneous breathing and heartbeat after a 10-minute resuscitation. The child had poor response and convulsion after resuscitation. Blood gas analysis showed metabolic acidosis, and amplitude-integrated EEG showed a burst-suppression pattern. She was diagnosed with sudden unexpected postnatal collapse but improved after hypothermia and symptomatic/supportive treatment. This article reports the first case of sudden unexpected postnatal collapse in China and summarizes related risk factors, pathophysiological mechanisms, and preventive and treatment measures of this disorder.
Subject(s)
Child , Child, Preschool , Female , Humans , Infant, Newborn , Pregnancy , Apgar Score , China , Resuscitation , Risk FactorsABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic values of prealbumin (PAB) and retinol-binding protein (RBP) for liver damage caused by mild or severe asphyxia.</p><p><b>METHODS</b>A retrospective analysis was performed on 185 neonates (including 84 premature infants and 101 full-term infants) with asphyxia. Based on the Apgar score, they were divided into two groups: mild asphyxia group (n=150) and severe asphyxia group (n=35). The levels of PAB, RBP, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured and compared. Their diagnostic values for liver damage were evaluated by ROC curve analysis.</p><p><b>RESULTS</b>The premature infants in the severe asphyxia group had significantly higher AST level and significantly lower levels of PAB and RBP than those in the mild asphyxia group (P<0.05). The full-term infants in the severe asphyxia group had a significantly lower PAB level than those in the mild asphyxia group (P<0.05). After treatment, the PAB level was significantly improved in the premature infants in the severe asphyxia group and in the full-term infants in both mild and severe asphyxia group (P<0.05). The full-term infants in the mild asphyxia groups also showed a significant improvement in AST level (P<0.05). The ROC curve analysis showed that PAB had a good sensitivity and specificity for identifying liver damage caused by mild or severe asphyxia in full-term and preterm infants.</p><p><b>CONCLUSIONS</b>PAB can be used as an indicator of liver damage caused by asphyxia in neonates, and can be used to assess the degree of asphyxia.</p>
Subject(s)
Female , Humans , Infant, Newborn , Male , Aspartate Aminotransferases , Blood , Asphyxia Neonatorum , Liver Diseases , Blood , Diagnosis , Prealbumin , Retinol-Binding Proteins , Serum AlbuminABSTRACT
A simple method has been proposed for the determination of clozapine (CLZ) and chlorpromazine (CPZ) in human urine by dispersive liquid-liquid microextraction (DLLME) in combination with high-performance liquid chromatography-ultraviolet detector (HPLC-UV).All important variables influencing the extraction efficiency,such as pH,types of the extraction solvent and the disperser solvent and their volume,ionic strength and centrifugation time were investigated and optimized.Under the optimal conditions,the limit of detection (LODs) and quantification (LOQs) of the method were 13 and 39 ng/mL for CLZ,and 2 and 6 ng/mL for CPZ,respectively The relative standard deviations (RSDs) of the targets were less than 5.1％ (C=0.100 μg/mL,n=9).Good linear behaviors over the tested concentration ranges were obtained with the values of R2＞0.999 for the targets.The absolute extraction efficiencies of CLZ and CPZ from the spiked blank urine samples were 98.3％ and 97.8％,respectively.The applicability of the technique was validated by analyzing urine samples and the mean recoveries for spiked urine samples ranged from 93.3％ to 105.0％.The method was successfully applied for the determination of CLZ and CPZ in real human urine.
ABSTRACT
Spiritual motivation is the basic means of mental reconstruction and behavior improvement.Medical ethics education is a process that fully develop medical resources,mine the essence of western traditional thinking of medical ethics,teach the basic principles of medical ethics,and medical ethics norms,play the role of medical model,train the noble medical ethics emotion,and develop good medical ethical behaviors.Based on the present situation of medical ethics education,this article explores the features of spiritual motivation and its application.